罗格于(Ben Wright 配音)和阿尼塔(Lisa Davis 配音)夫妇饲养的大麦町狗庞哥(Rod Taylor 配音)与帕蒂塔(Cate Bauer 配音)喜结良缘,共组成欢乐家庭。没过多久,帕蒂塔生育了十五只小狗。正在一家人享受小狗带来的欢乐之际,阿尼塔的女上司克鲁拉·德维尔(Betty Lou Gerson 配音)打起了坏主意。她正在为制作一件黑白斑点的大衣而发愁,于是她派人绑走了小狗,和其他八十四只大麦町幼犬一同关在乡间的空屋里。发现孩子失踪的庞哥与帕蒂塔,通过狗吠召集全市的狗类,一同找寻自己的孩子,一场小狗救援记就此展开,庞哥与帕蒂塔能否在小狗被宰杀之前营救他们逃出呢……
《101斑点狗》是迪士尼1961年推出的第17部经典动画,取材自Dodie Smith 的作品。
Ralph Burton is a miner who is trapped for several days as a result of a cave-in. When he finally manages to dig himself out, he realizes that all of mankind seems to have been destroyed in a nuclear holocaust. He travels to New York City only to find it deserted. Making a life for himself there, he is flabbergasted to eventually find Sarah Crandall, who also managed to survive. Together, they form a close friendship until the arrival of Benson Thacker who has managed to pilot his small boat into the city's harbor. At this point the tensions rise between the three, particularly between Thacker, who is white and Burton, who is black.